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If the Poll Everywhere app for Windows PowerPoint does not work as expected, the cause may be related to file permissions. Features like presenting a Poll Everywhere activity are turned off when a presentation is in read-only or protected mode. It might be necessary to manually modify the file's permissions or trust the file differently to present your activities.
Read-Only Presentation
When PowerPoint opens a read-only file it will not allow modifications to the file until read-only flags are removed.
Step 1. Click File > Info
Step 2. Review the Presentations status.
Step 3. Right-click File > Properties
Step 4. Uncheck read-only.
Protected Presentation
When a PowerPoint file is downloaded from the Internet it is opened in protected mode until the user decides to trust and edit it.
Step 1. Click File > Options
Step 2. Click Trust Center > Trust Center Settings > Protected View
Step 3. Uncheck Enable Protected View for files originating from the internet.
In some cases moving the file to a trusted location like the Desktop can cause PowerPoint to trust the file.
References
If you continue to have trouble please gather your logs and contact support.